Crn: Flawed Study Might Nevertheless Have Yielded Positive Results If Allowed To Run Course
Steve Mister, president and CEO of CRN, said the study had many shortcomings, not least of which was to assume that a very short term, high dose application would perform like a drug would.
The study is plagued by a poor, open-label design, insufficient number of participants, substantial differences in the health status of participants by group, and the expectation that essential nutrients should behave like high-powered pharmaceuticals, he said.
Mister said his organization believes the researchers may have pulled the plug too soon. He noted that the data gathered from less than half of the target subject pool showed a trend toward benefit in the groups that received the vitamin C alone or that took vitamin C along with zinc. The study might have shown a statistically more robust result if allowed to run its full course.
atients who received vitamin C or vitamin C and zinc achieved a 50% reduction in their symptoms 1.2 days sooner than the standard of care group, however this finding did not achieve statistical significance by the time the study was prematurely terminated for futilityhaving enrolled less than half the intended number. If the study had fully enrolled, the differences in outcomes between groups may have reached statistical significance, he said.
Randomized Clinical Trial Of Zinc Plus Hydroxychloroquine Versus Hydroxychloroquine Alone In Hospitalized Patients With Covid
In a randomized clinical trial that was conducted at three academic medical centers in Egypt, 191 patients with laboratory-confirmed SARS-CoV-2 infection were randomized to receive either zinc 220 mg twice daily plus hydroxychloroquine or hydroxychloroquine alone for a 5-day course. The primary endpoints were recovery within 28 days, the need for mechanical ventilation, and death. The two arms were matched for age and gender.8
- There were no significant differences between the two arms in the percentages of patients who recovered within 28 days , the need for mechanical ventilation , or overall mortality .
- The only risk factors for mortality were age and the need for mechanical ventilation.
- The study had a small sample size.
- There was no placebo control.
In outpatients with COVID-19, treatment with high-dose zinc gluconate, ascorbic acid, or a combination of the two supplements did not significantly decrease the number of days required to reach a 50% reduction in a symptom severity score compared with standard of care.
Zinc And Immune System
Evidence suggests that Covid-19 is more common in people with compromised immunity. A strong immunity is a collective outcome of many factors, diet being one of them.
Antioxidant nutrient zinc affects multiple aspects of the immune system. Zinc is needed for normal development and function of cells mediating innate immunity, neutrophils, and Natural Killer cells.
Macrophages, which are responsible for engulfing foreign pathogens by a process called phagocytosis, are also affected by zinc deficiency. Zinc deficiency leads to the growth and function of T and B lymphocytes. Zinc also functions as a potential antioxidant to prevent free radical-induced injury during inflammatory processes.
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/7foods Rich In Vitamin D
There was a study published in the journal Nature in May 2021 in Telangana by the doctors at Nizams Institute of Medical Sciences and Gandhi Hospital on local Covid positive patients. The study indicated that adding Vitamin D in the treatment protocols will lead to improved outcomes i.e., recovery of Covid positive patients. Seeing this study, we can clearly say that foods rich in this vitamin D can prove to be important while recovering from Covid-19 variants. Thus, one must include foods like mushrooms, egg yolk, yoghurt and milk in diet. An hour of sitting in the sun is also important.
Can Zinc Cause Side Effects
Yes. Zinc is a trace mineral which means we need a certain amount of it each day but taking high doses of zinc supplements can cause toxicity.
Side effects of zinc include nausea, vomiting, a loss of appetite, a bad taste, and a loss of smell.
High zinc can also inhibit the absorption of copper, which may result in copper deficiency and anemia.
Zinc supplements may also interact with medicines such as antibiotics, diuretics, and penicillamine.
You cannot over-consume zinc from zinc-containing foods.
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Zinc Ion And Zinc Ionophore As Virus Blockers
SARS-COV-2, the virus that causes Covid, is an RNA virus.
An RNA virus is a virus that has RNA as its genetic material. RNA-dependent RNA polymerase enzymes are the core enzymes of the RNA viruss RNA-synthesizing machinery. Thus, RdRps are key targets for antiviral research.
In a study published this week, it was demonstrated that concentrations of intracellular zinc ion efficiently impaired the replication of RNA viruses, including Covid and arteriviruses by blocking RdRp activity.
In cell culture studies, high Zn2+ concentrations and addition of ionophores such as hinokitiol , pyrrolidine dithiocarbamate and pyrithione were found to inhibit the replication of various RNA viruses, including influenza virus and respiratory syncytial virus.
It Keeps Your Immune System Healthy
It appears that every immunological event relates in some way to zinc. Theres a strong connection between zinc deficiency and susceptibility to disease. A Cochrane Library meta-analysis of six studies that included a total of over 5,000 children between two months old and five years of age found that zinc supplementation reduced the incidence of pneumonia. And according to findings from a 2011 Cochrane review, zinc effectively shortens the duration and severity of the common cold .
People who are infected by Covid 19 and are zinc-deficient develop more complications, are more likely to require hospitalization, have longer hospital stays, and are more likely to die. While theres not yet enough evidence to officially recommend zinc for the prevention or treatment of COVID-19, especially in amounts that exceed the RDA, research is ongoing for its potential use, and some initial studies have been promising.
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It Helps Regulate Hormones
Zinc plays a huge role in regulating your hormones, including growth hormone, insulin, leptin, thyroid hormone, melatonin, and sex hormones. Getting enough zinc is important for the functioning of your endocrine system. When it isnt, your various organs and systems cant communicate well, which can wreak havoc on your health, your energy, and your mood.
Know That Your Vaccine Didnt Fail
A breakthrough infection is not a sign that the vaccines dont work, several of the experts emphasize. While vaccinated people are less likely than unvaccinated individuals to contract COVID, the main job of the vaccines is to prevent death, and federal data shows theyre still doing that.
This is not an indication that the technology behind the vaccine has failed, Springgate says. This is a recognition that this is a brand-new organism, a brand-new virus that has newly mutated and is able to evade the prior two-dose series. The current booster shot seals in an added layer of protection, and it may be the case going forward that another is needed, he adds. All three vaccine makers have announced that they are testing omicron-specific vaccines that could be available as early as this spring.
Rachel Nania writes about health care and health policy for AARP. Previously she was a reporter and editor for WTOP Radio in Washington, D.C. A recipient of a Gracie Award and a regional Edward R. Murrow Award, she also participated in a dementia fellowship with the National Press Foundation.
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It May Help Protect Against Neurodegenerative Disorders
No, zinc is not the fictional brain-enhancing drug NZT-48 from the movie Limitless. Taking it wont make you smarter, or make you rich and powerful .
Now the good news. Many people can prevent age-related neurodegenerative disorders, like Alzheimers, with diet and lifestyle habits. Getting enough zinc is a key part of this prevention strategy it acts as an antioxidant, preventing oxidative stress in the brain that could otherwise increase your risk for neurodegeneration. In fact, an imbalance of iron and zinc ions has been shown to lead to Alzheimers and Parkinsons disease symptoms.
In The Current Situation Zinc Emerges As An Important Element Of Choice For The Management Of Covid
The second wave of covid-19 infections has proven to be even more contagious and fatal than the first one. This has even resulted in an excess burden on the healthcare system, coupled with a shortage of vaccines, beds, ventilators, oxygen, and medicines. As such, it becomes extremely important for people to take care of their health by eating healthy, exercising and following all appropriate protocols.
In the current situation, zinc emerges as an important element of choice for the management of Covid-19 symptoms along with anti-infective and other antiparasitic drugs, according to Dr Scott Read, senior lecturer, School of Medicine at Western Sydney University, Australia.
Dr Scott cited several studies in support of the effectiveness of zinc 50 mg daily in cases of SARs-CoV2 or coronavirus. According to a research paper published by Advances in Integrative Medicine Journal, zinc might potentially reduce the risk, duration and severity of SARS-CoV-2 infections, particularly for populations at risk of zinc deficiency including people with chronic disease co-morbidities and older adults.
Dr Scott said, Zinc deficiency has been associated with an increased susceptibility to infectious diseases, including viral infections. Studies have shown that the zinc status of an individual is a critical factor that can influence immunity against viral infections.
Why 50mg zinc?
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The Protective Power Of Zinc
Before we get into the ins and outs of zinc, a story:
One day, early in the 19th century, the Royal Navy came to the chemist and inventor Sir Humphrey Davy with a big problem. To protect their ships from a kind of mollusk that bored into wood, ship makers had been lining the bottoms of these vessels with copper. Unfortunately, the saltwater quickly corroded the copper, which led to costly and highly inconvenient repairs. Could Davy come up with a solution?
Davy suggested attaching a sacrificial metal to the copper. His element of choice was zinc. The zinc would protect the copper by being degraded by the saltwater, a process termed galvanization that later protected iron, steel, and other industrial metals from corrosion.
The story ends sadly for Davy and the Navy . While the zinc stopped the deterioration of the copper, it also made it far more susceptible to weeds and barnacles by providing them with nutrients that they found appealing. But it highlights the power of zinc, which can protect not only copper and iron but us as well.
Zinc Balances The Immune Response During Infectious Diseases
One of the hallmarks of COVID-19 is an imbalanced immune response . Due to hyper-inflammation, immune products including pro-inflammatory cytokines like interleukin -6, C-reactive protein , tumor necrosis factor and IL-1 , reactive oxygen, and nitrogen species in connection with the recruitment of high numbers of strongly activated immune cells to the lungs, the destruction of the tissue, permanent lung damage and death due to systemic inflammation, and organ failure are expected, while the anti-inflammatory response is insufficient . A high number of patients develop an acute respiratory distress syndrome accompanied by high alveolar leakage leading to alveolar and interstitial edema with severely limited oxygen exchange . Advanced SARS-CoV2 infections are characterized by a systemic involvement with organ complications and accompanying cytokine storm .
Clinical improvement of COVID-19 patients was correlated to an increase of CD14+ monocytes and NK cells in the recovery phase . For a physiological inflammatory response and phagocytic activity macrophages need sufficient intracellular zinc levels . In addition, for NK cells and cytotoxic T cells it was shown that zinc supplementation increased their cytotoxicity toward target cells .
In summary zinc’s balancing power regarding immune cell numbers and functions might be highly beneficial in regard to therapy of COVID-19.
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Zinc May Interact With Medications
If youre planning to take zinc supplementseven just for the duration of a coldyou should talk to your doctor about whether zinc will interact with any other medications youre taking. For example, taking zinc with certain antibiotics can lower both the amount of the medication and the amount of zinc your body absorbs. Zinc supplements can also interfere with the effectiveness of certain rheumatoid arthritis drugs.
Scientists Are Excited By The Possibility Of Zinc Emerging As One Of The Promising Candidates To Reduce The Severity Of Covid 19 Infection Read On To Know More
Written by Editorial Team | Updated : May 21, 2021 7:27 AM IST
The second wave of COVID-19 infections has shaken India. This wave is even more contagious and fatal than the first. Between April 25 and May 2, India reported 29.44 lacs cases, which is the highest number of cases reported by any country in any 7 days’ period since the beginning of the pandemic. The excess burden on healthcare system is also being reflected in the alarming growth rate of deaths in the period. Shortage of vaccines, beds, ventilators, oxygen and medicines makes this situation even worse. In the current situation, Zinc emerges as an important element of choice for the management of COVID-19 symptoms along with anti-infective and other antiparasitic drug. Even in the present scenario, governments of Uttar Pradesh, West Bengal, Maharashtra, and Assam have already included zinc along with other nutraceuticals, anti-infectives, corticosteroids & antiparasitic, etc drugs in their protocol for the management of COVID-19.
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Synergistic Action Of Nutrients On Physical Barriers
The outer and inner surfaces of an organism, such as the skin and mucous membranes, are the first line of defense against pathogens, toxins and other foreign bodies, as they form physical barriers that prevent entry . SARS-CoV-2 is able to penetrate physical barriers when they are vulnerable. Thus, it can be transmitted directly, when there is physical contact with the infected person, or indirectly, when the infection occurs through droplets and aerosols in suspension or through fomites, where steel and plastic are the materials in which this virus is more viable .
Droplets containing SARS-CoV-2 are transmitted when they come in contact with the oral, respiratory tract and intestinal mucosa and the conjunctiva, tissues that express ACE2 necessary for the entry of this virus into the body. However, whether the consumption of food contaminated with SARS-CoV-2 can cause its transmission through the digestive system remains to be confirmed . Thus, the physical and functional integrity of the physical barriers, especially epithelial cells, is important for reducing the risk of SARS-CoV-2 contagion.
The epithelial cells are joined by distinct intercellular junctions, known as the epithelial junctional complex, which is formed by tight junctions, adherens junctions and desmosomes . Because they act as a selective barrier, this complex prevents the entry of pathogens and toxins into the bloodstream.
Should You Take Zinc For A Cold Or Covid
This immune-boosting mineral has been popular during the pandemic. Heres a look at what it can actually do.
Although many of us are getting fewer colds this year than usual , were also more concerned than ever with keeping our immune systems strong. For some, that means reaching for supplements thought to boost your bodys defenses, and zinc is one of the more popular choices. According to estimates from Nutrition Business Journal, consumers spent $162 million on zinc supplements in 2020, a 35 percent increase over the previous year.
Zinc has a reputation for ending colds more quickly and helping you feel better faster. But as with many supplements, the science surrounding the claims still hasnt quite caught up to consumer interest.
We know that people take it a lot, but we also know there isnt a lot of scientific validation for zinc supplementation, says Suma Thomas, MD, a cardiologist at the Cleveland Clinic who has studied the possible effects of zinc supplements on COVID-19 patients.
Zinc supplements arent regulated by the Food and Drug Administration in the same way that medications are. So before you decide to spend your money on zinc pills or lozenges, keep these five points in mind.
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Association Of Zinc Deficiency With Severe Covid Outcomes Has Probably Labelled Zinc As The Second Most Important Nutrient After Vitamin D That Can Help Fight The Virus
New Delhi: In the ongoing Covid-19 pandemic, the importance of zinc has been documented by several scientific studies.
Association of zinc deficiency with severe Covid outcomes in patients has probably labelled zinc as the second most important nutrient after Vitamin D that can fight against the novel coronavirus. Across the globe, zinc has also been recognised as one of the indispensable components in standard Covid treatment plan.
Zinc is an essential element for the human body responsible for catalytic activity of more than 100 enzymes, adequate functioning of the immune system, synthesis of genetic materials, and maintaining cell integration.
Being an essential nutrient, zinc cannot be produced or stored in the body and needs to be supplemented through diet. An adult Indian needs 10-15 mg/day zinc to meet the recommended dietary allowance.
Oysters are the best-known sources of zinc. Other food sources include sea foods like crab, lobster, animal sources like red meat, poultry, and plant sources such as beans, nuts, whole grains and fortified breakfast cereals.
/7foods To Eat While Recovering From Coronavirus
With the new year 2022, we hoped for new beginnings when we could be free from the pandemic and could live a normal life. But, it seems that the pandemic is here to stay as there again is a surge in coronavirus cases with more and more people getting infected with the new variant, Omicron. There has been a sudden jump in Omicron cases and the current stats revealed by the Ministry of Health & Family Welfare state that the active cases are 1,71,830. Though the experts agree that this wave is likely to be short-lived, one must stick to the norms given by the government where they urge people to take precautions while going out. However, even then if one catches the coronavirus infection, one must pay special attention to the diet as it has an important role to play in recovery. It is important that one must take lots of fluids along with foods that are rich in zinc, vitamin C and protein.
According to Dr Vishnuraj Prakash, Head of Ayurveda, Vana Retreat, Dehradun, our immunity helps our physiological system to resist any bacterial or viral invasion. One needs to understand that a balanced immune response is vital to ward off these infections and bounce back to health. Here are some of the foods that you must include in your diet if you are recovering from COVID 19.
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