Why Zoo Animals Are Getting Covid
Although dogs and cats have tested positive for COVID-19 in a smattering of cases around the world, the Centers for Disease Control and Prevention and the World Small Animal Veterinary Association dont recommend vaccinating pets, due to their relatively mild clinical signs and the lack of evidence that pets can transmit the virus to humans.;
It remains our opinion that there is no need for owners to consider vaccinating their pets against SARS-CoV-2 at this time, notes WSAVA in an .
Between zoo visitors and animal caretakers, the chances of a zoo animal getting exposed to the virus is higher, Zoetiss Kumar says. When compared to lions and tigers, I wouldnt say that cats are less susceptiblejust that the cat is getting exposed to people probably a lot less.;
Any request to vaccinate a cat or dog would have to go through the same process as vaccine requests for zoo animals, with individual approval from the USDA and state veterinarian. You can imagine if we got 100,000 requests for cats and dogs. So its not a practical way for us to supply it, says Kumar.;
Vaccinations for cats and dogs would depend on the government soliciting and authorizing broad commercial use, he says. The USDA is currently only accepting applications for animal COVID-19 vaccines for mink, so unless that changes, the Zoetis vaccine will only be available for other species on an experimental, case-by-case basis.;
Did The Oxford Covid Vaccine Work In Monkeys Not Really
The day after data appeared from the vaccine maker Sinovac showed complete protection of rhesus monkeys by their vaccine candidate , scientists from the;Jenner Institute in Oxford issued a press release announcing that their;vaccine worked to protect rhesus monkeys and that they were moving forward with large scale;human safety trials. At the time, the;substantiating data was not;available. Now it is, in the form of a May 13 BioRxiv preprint. Does the data support the claim?
Not really. All of the vaccinated monkeys treated with the Oxford vaccine became infected when challenged,;as judged by recovery of;virus genomic RNA from nasal secretions. There was no difference in the amount of viral RNA detected from this site in the vaccinated monkeys as compared to the unvaccinated animals. Which is to say, all vaccinated animals were infected.;This observation is in marked;contrast to the results reported from Sinovac trial. At the highest dose studied, no virus was recovered from vaccinated monkeys from the throat, lung, or rectum of the vaccinated animals.;
What then is the argument for pressing forward with the adenovirus vector SARS-CoV-2 spike protein vaccine?
The authors present evidence to the effect that, although the vaccine did not protect the animals from infection, it did moderate the disease.;
Pfizer And Biontech Announce Data From Preclinical Studies Of Mrna
- Immunization of non-human primates with BNT162b2, a nucleoside-modified messenger RNA candidate that expresses the SARS-CoV-2 spike glycoprotein, resulted in strong anti-viral effects against an infectious SARS-CoV-2 challenge
- BNT162b2 immunization prevented lung infection in 100% of the SARS-CoV-2 challenged rhesus macaques, with no viral RNA detected in the lower respiratory tract of immunized and challenged animals. The BNT162b2 vaccination also cleared the nose of detectable viral RNA in 100% of the SARS-CoV-2 challenged rhesus macaques within 3 days after the infection
- The BNT162b2 vaccine candidate induced SARS-CoV-2 neutralizing antibodies in rhesus macaques, pseudovirus neutralizing antibodies in mice, and strong, antigen-specific CD4+ and CD8+ T cells in mice and macaques
NEW YORK & MAINZ, Germany—-Pfizer Inc. and BioNTech SE today announced preliminary preclinical data in mouse and non-human primate models from their BNT162b2 mRNA-based vaccine program against SARS-CoV-2, the virus that causes COVID-19 disease. In a non-human primate preclinical study, immunization with the BNT162b2, a nucleoside-modified messenger RNA candidate, protected rhesus macaques against SARS-CoV-2 infection. The manuscript describing these preclinical data is available on a preprint server at and is concurrently undergoing scientific peer-review for potential publication.
About Pfizer: Breakthroughs That Change Patients Lives
Safety And Efficacy Of Covid
Animals are also key for evaluating the protective efficacy and safety of any new treatments, including COVID-19. Mice, specially bred for studying COVID-19 are being used by Professor Xiao-Ning Xu at Imperial College London, who has MRC funding to test a monoclonal antibody treatment that may be effective against different types of coronaviruses including SARS-CoV-2. Professor Xu will also test these monoclonal antibodies in monkeys at the UKs National Institute for Biological Standards and Control, because human antibodies are more likely to interact with other components of the immune system in species that are closely related to us, compared to mice.
The UKs extensive scientific expertise is ideally positioned to lead the way in responding to the threat posed by the COVID-19 pandemic. This expertise is only possible because of the decades of knowledge gained from funding excellent discovery science, and the advances gained from research involving animals.
Visit this Interactive Global Map;to see where Covid-19;research involving animal models is located in the world. For more information on how animal research is contributing to research on coronavirus, and to medicine in general, visit Understanding Animal Research.
All Four Vaccines Approved For Use In Ireland Have Been Tested On Animals As Well As Humans
A NUMBER OF posts circulated on social media recently have claimed Covid-19 vaccines which have been approved for use did not go through animal trials as part of their development process.
The above post has been widely circulated on Facebook by various different pages and individuals, with some shared hundreds of times.;
Commentators in videos on both Facebook and Instagram who acknowledge trials did take place have claimed that vaccines approved across the world failed animal trials.
These claims are false.
The European Medicines Agency , the regulatory body that has approved the four vaccines currently being used in Ireland, requires vaccine developers to provide data from animal trials.
The US Food and Drug Administration also requires results from laboratory testing in animals as part of the Emergency Use Authoriazation process for Covid-19 vaccines.
The animal trials are part of the non-clinical phase, before the widely publicised clinical trials on humans. These in vivo studies show how the vaccine triggers an immune response and works to prevent infections.
All four vaccines in use in Ireland Pfizer/BioNTech, Moderna, AstraZeneca and Janssen have conducted and published data on animal trials.
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Clip From Texas Senate Hearing
The video in the Instagram post shows a May 6 Texas Senate hearing during which a state senator and pediatrician promote;misinformation about the coronavirus pandemic.
During the hearing, a Texas Senate committee heard from about 200 people who support a bill that would ban mandatory COVID-19 vaccinations; including requirements from private employers. One of those people was Dr. Angelina Farella, a pediatrician in Webster, Texas.
“I’ve given tens of thousands of vaccines in my office. I am;not an anti-vaxxer,” she said during the hearing. “I’m very pro-vax actually ;except when it comes to this COVID vaccine, if we can call it that.”
Over the course of her testimony to the Texas Senate, Farella doubted the safety of the coronavirus vaccine by;saying it’s been linked to more than 4,000 deaths. ; After her testimony, she spoke with Republican state Sen. Bob Hall about animal testing.
Here’s that exchange, in context:
Hall: “Have you seen any other vaccine that was put out for the public that skipped the animal test?”
Farella: “Never before, especially for children.”
Hall:;“What I’ve read, they actually started the animal test, and because the animals were dying, they stopped the test.”
Farella and Hall have both previously made claims;that run contrary to the scientific consensus about the coronavirus pandemic.
USA TODAY reached out to Farella’s and Hall’s press offices for comment.
Can I Get A Covid
The goal of being vegan and advocating for animal rights should always be to bring about positive change for animals. As long as tests on animals are a legal requirement, refusing to take a medicine on ethical grounds will not help animals who have already been used in tests or spare any the same fate in the future.
What needs to happen is a change in the law so that animals are no longer required to suffer in tests, and you can most effectively bring this about by using your voice to speak out for animals in laboratories and supporting our work. To keep yourself and others as fit and healthy as possible and allow you to continue advocating for animals please follow the advice of your health-care provider on taking a medicine.
Urge the Government to End to All Experiments on Animals
Recommended Reading: Breastfeeding Instead Of Vaccination
To Develop A Coronavirus Vaccine Synthetic Biologists Try To Outdo Nature
The question is complicated by the newness of the science at play. The technology that has allowed Moderna to craft an experimental vaccine so fast has not yielded a single immunization thats made it to market so far. Its a trendy idea: Instead of injecting people with a weakened pathogen or proteins from the surface of a pathogen, so that our bodies will learn to fight off such infections in the future, scientists are betting on a kind of genetic hack, a lab-made concoction that gets the body to produce its own virus-like bits which it will then train itself to combat.
At the center of it all is a molecule called messenger RNA, or mRNA. Inside of us, its normal function is to transmit the instructions contained within our DNA to the cellular protein-making factories that carry them out. In Modernas recipe, the mRNA is synthetic, programmed with the goal of getting our inner machinery to produce certain coronavirus-like proteins the very proteins that the pathogen uses to gain entry into our cells. Once those homemade dummy virus particles are there, the thinking goes, our bodies will learn to recognize and clobber the real thing.
Those mice in the U.S. are being bred so that the colony can be enlarged, explained Graham, adding, that they will be available for experiments within the next few weeks.
Damian Garde contributed reporting.;
Pfizer And Moderna Did Not Skip Animal Trials
CLAIM: The Pfizer and Moderna vaccines are mRNAs vaccines that skipped animal trials because using mRNA vaccines on animals triggers dangerous inflammation.
APS ASSESSMENT: False. Pfizer and Moderna did not skip animal trials when testing their COVID-19 vaccines.;
THE FACTS: As the race to authorize the use of COVID-19 vaccines continues, posts online are spreading misinformation about vaccine trials.;
Recent posts are criticizing Pfizer and Moderna, who both announced that their vaccines were more than 90 percent effective at preventing COVID-19. One tweet with more than 4,000 likes suggests that the two companies did not conduct animal trials when testing their vaccines because testing mRNA vaccines on animals could cause dangerous side effects.;
The vaccines from Pfizer-BioNTech and Moderna both rely on messenger RNA. MRNA vaccines contain a genetic code that trains the immune system to recognize the spike protein on the surface of the virus to generate an immune response.;
Due to the urgent need for a vaccine in a surging pandemic, Pfizer and Moderna were given approval to simultaneously test their vaccines on animals while they were conducting Phase 1 trials on humans. The vaccines were tested on mice and macaques.;
Posts online appeared to suggest that the animal trial phase was skipped completely when testing the two vaccines.;
While mRNA is a new technology, experts have been working on it for years.;
Now they are going to go after the COVID-19 vaccine, Dr. Hotez said.;
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Clinical Criteria For Sars
Clinical criteria for considering testing for SARS-CoV-2 in animals is based on what is currently known about SARS-CoV-2 and COVID-19 and is subject to change as additional information becomes available. Visit;CDCs COVID-19 and Animals page;for the most up-to-date information on SARS-CoV-2 infection in animals.
Humans with COVID-19 often have;symptoms;that appear 2-14 days after exposure and include fever, cough, and shortness of breath. Like people, some animals with SARS-CoV-2 infection are asymptomatic, while others may present with a combination of respiratory or gastrointestinal illness.
Clinical signs suspicious of SARS-CoV-2 in animals include:
Veterinarians should use their best judgment to determine if an animal has been exposed to people with suspected or confirmed COVID-19 and if the animal has clinical signs compatible with SARS-CoV-2 infection .;Table 1;describes epidemiological risk factors and clinical features that can help guide decisions regarding animal testing.
Table 1: Criteria to Guide Evaluation and Laboratory Testing for SARS-CoV-2 in Animals;
NOTE: Veterinarians are encouraged to consider other, more common causes of illness in animals and use their clinical judgement when deciding whether or not to test animals for SARS-CoV-2.
Exploring Pharmas Interest In Genoskin
Genoskin has worked with big pharma, small biotechs and academic researchers on its skin models. For instance, the company has worked with Sanofi on the responses to the subcutaneous injection of adalimumab, a drug indicated for various autoimmune conditions, in a skin model that reproduces psoriatic lesions.;
Genoskin has also worked with the chemicals company Clariant to study mitigating skin inflammaging by inhibiting the NLRPE inflammasome and NFkb pathways and with Harvard University on mapping the distributions of metal and metal oxide in ex vivo skin.;
The ability to have an immunocompetent tissue that is injectable are two things that set us completely apart.
Industry and academia are not the only stakeholders in the pharma industry to be interested in Genoskin. The company recently met with regulators in both the US and Europe, which are interested in moving away from animal testing and the possibilities of the alternatives.;
Interest from the pharma industry in Genoskin peaked with the launch of the worlds first injectable platform; this model can receive injections because it contains the hypodermis or fatty layer between the dermis and epidermis. The ability to have an immunocompetent tissue that is injectable are two things that set us completely apart and have transformed our company in the past two years, notes Merle.;
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In Other News: The Latest Social Media Platform Is A Hotbed Of Misinformation
A new social media platform launched by a former spokesman for former US president Donald Trump has been inundated with misinformation, just days after its launch.
According to misinformation researchers at;First Draft, Gettr, which was officially launched on July 4 but had been already available in beta form for several days, has played host to QAnon-affiliated accounts spreading falsehoods about the November 2020 presidential election.
“Links to debunked videos that purport to show 2020 ballots being manipulated or destroyed in various US states have also been liked nearly 2,000 times on Gettr,” First Draft found.
Other election misinformation shared on the platform includes incorrect claims of fraud in Arizona’s vote-counting process.
“Previous audits in Arizona have been completed and no problems were uncovered,” First Draft reiterated, noting;reports;by National Public Radio in the US indicating that the latest auditing process ordered up by state Republicans was being run by a company with no prior election experience and led by a CEO who has himself spread election-related misinformation.
The rampant misinformation appearing on the site is hardly surprising, with The Daily Beast;reporting;that Gettr was being bankrolled by a Chinese billionaire who was recently;found;by network analysis company Graphika to be behind a massive online disinformation network.
Gizmodo, meanwhile,;reported;that the site had absolved itself of moderation responsibilities.
I Wont Be Accepting The Vaccine After What Has Been Done To So Many Defenceless Animals It Feels Wrong To Me Writes Chas Newkey
Everyone loves a monkey, right? They are cute, clever and cheeky. Most of us feel warm and at peace with life when we see pictures and nature documentaries of them playing and swinging through trees.
They are our closest cousins. Loveable creatures. Some parents even call their children cheeky monkeys.
But what about the monkeys that spend their whole lives restrained in laboratories, with scientists hurting them to see what happens?
The hunt for a coronavirus vaccine has been horrendous for some animals. As part of the drive to save human lives, thousands of cheeky monkeys, ferrets, cats, mice and hamsters have been deliberately infected and experimented on in labs.;
Also Check: How Long Cvs Covid Test Results
Vegan Doctors And Animal Testing
Speaking about the vaccine, Dr. Bitterman says there was animal testing as with any other medical product. Speaking specifically about the Pfizer vaccine, he says 106 animals in total were used in testing . This breaks down into 64 mice and 42 macaque monkeys. When it comes to another vaccine , he says the data isnt as clear, but he believes the number to be similar.
However, he believes refusing to take the vaccine on animal testing grounds is not analogous to rejection of other products, suggesting several reasons.
Number one, youre not creating more demand, so its not like when you look at cosmetic products, he said. If you purchase a cosmetic product thats been tested a company that tests on animals, they have a tendency to say okay were going to have our sales, and then were going to have another product that were going to put in the line once the sales peter outand then were going to test on more animals.
This is not how it works in pre-clinical testing for approved pharmaceuticals. The testing is already done. You taking the vaccine is not going to incentivize anyone else to test this vaccine on further animals.
Im not going to defend animal testing. I think it is unfortunate what happened to those animals. In many cases, if not all, the animals are euthanizedhowever, if you contrast that to the number of people saved, and the expected number of people saved, its astronomical.