What’s In Pfizer’s Covid
When the Pfizer COVID-19 vaccine received an EUA from the FDA, its ingredients list was published online in a fact sheet for vaccine recipients and caregivers. This is the full list of ingredients, according to the FDA:
- Lipids azanediyl)bisbis, 2 -N,N-ditetradecylacetamide, 1,2-Distearoyl-sn-glycero-3- phosphocholine, and cholesterol)
- Potassium chloride
What Is An Emergency Use Authorization
Three vaccines Pfizer, Moderna, and Janssen have received Emergency Use Authorization from the federal Food and Drug Administration. Pfizer has also been approved for people ages 16 and older. Learn more about what this means and other information about the vaccines in the FDA fact sheets for recipients and caregivers: Comirnaty/Pfizer, Moderna, and Johnson & Johnson .
Many More Questions Still Need Answers
There are still many questions left to answer about Covid-19 vaccines and immunology, John Wherry, director of the Institute for Immunology at the University of Pennsylvanias Perelman School of Medicine, wrote in an email to CNN.
Those questions include: How long do memory B cells and memory T cells last? How do the vaccines containing the original coronavirus, identified in Wuhan, China, induce effective immune memory against all the variants so far? What immune mechanisms provide protection from infection versus protection from severe disease, hospitalization and death? Why do different people respond differently to these vaccines?
These and many more questions still need answers if we are going to use this platform most effectively, Wherry wrote. Such questions also need answers in the context of vaccine durability, especially as the durability of protection and the durability of immune responses themselves are related but not the same, according to Wherry.
For the mRNA vaccines, durability of protection is on par with other vaccine types from the analyses we have seen on the adenoviral platforms versus mRNA. Durability of immune responses its been difficult to do really precise comparative studies longitudinally over a time frame relevant to answer this question, Wherry wrote in his email.
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Guns Trucks And Trips: West Virginia Expands Prizes For Vaccinated Residents
Goepfert says it’ll be a good thing if all these vaccines make it to consumers. But that alone isn’t going to solve the problem of getting people vaccinated.
Why? “Because the vaccines that we have now are just beyond our wildest dreams kind of effective,” he says. “And I’m living in a state right now where it just frustrates me how slow our vaccine uptake is.”
Goepfert lives in Alabama. According to the latest numbers from the Centers for Disease Control and Prevention, only Mississippi has a lower per capita rate of vaccination.
Is Mrna Technology Safe
Although this is the first time mRNA technology has successfully been used in a vaccine, it has been in development for over a decade, with many studies and trials taking place over the past few years.
MRNA vaccines present the body with a set of instructions to help it trigger creation of the antibodies to fight coronavirus. It cannot change the DNA of a human cell.
According to Jonas Nilsen, MD and co-founder of Practio “although this is the first time mRNA vaccines have been approved for use in the UK, mRNA technology has been studied and developed for decades. The development of an mRNA vaccine is a breakthrough that could result in vaccines being developed more quickly in the future.
Both the Pfizer and Moderna vaccines have been tested on tens of thousands of people, and have been proven to be both highly effective and safe.”
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Myth: Researchers Rushed The Development Of The Covid
FACT: Studies found that the two initial vaccines are both about 95% effective and reported no serious or life-threatening side effects. There are many reasons why the COVID-19 vaccines could be developed so quickly. Here are just a few:
- The COVID-19 vaccines from Pfizer/BioNTech and Moderna were created with a method that has been in development for years, so the companies could start the vaccine development process early in the pandemic.
- China isolated and shared genetic information about COVID-19 promptly, so scientists could start working on vaccines.
- The vaccine developers didnt skip any testing steps, but conducted some of the steps on an overlapping schedule to gather data faster.
- Vaccine projects had plenty of resources, as governments invested in research and/or paid for vaccines in advance.
- Some types of COVID-19 vaccines were created using messenger RNA , which allows a faster approach than the traditional way that vaccines are made.
- Social media helped companies find and engage study volunteers, and many were willing to help with COVID-19 vaccine research.
- Because COVID-19 is so contagious and widespread, it did not take long to see if the vaccine worked for the study volunteers who were vaccinated.
- Companies began making vaccines early in the process even before FDA authorization so some supplies were ready when authorization occurred.
The COVID-19 Vaccines: What you need to know | Las vacunas anticovid-19: información imprescindible
Vaccine Development: Vaccines Approved For Use And In Clinical Trials
The speed at which the first COVID-19 vaccines were developed was extraordinary. We have previously looked into the history of vaccine development. The measles vaccine was found relatively rapidly: it took only 10 years from the discovery of the pathogen to the development of the first vaccine. But for typhoid it took more than a century, and for some diseases for which weve known the pathogens for more than a century we still havent found an effective vaccine.
The development of a vaccine against COVID-19 has been much faster than the development of any other vaccine. Within less than a year several successful vaccines have already been announced and were approved for use in some countries.
The hope is that even more manufacturers develop vaccines for COVID-19. This will be important because eventually a very large share of the world population needs to receive a COVID-19 vaccine.
We are on the way to several vaccines against COVID-19 vaccine trackers monitor the progress:
Several institutions maintain websites on which they list COVID-19 candidate vaccines that are currently being developed:
|Oxford/AstraZeneca, Sinopharm/Beijing, Sinovac, Sputnik V|
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What Are The Ingredients Of Pfizers Covid
We asked experts to help us decode the contents.
Facebook said on December 3 that it would remove posts with false claims or conspiracy theories about whats in the covid-19 vaccines that everyones counting on.
In the face of rumors suggesting that Bill Gates has installed tracking microchips in the shots, or that the inoculations contain luciferase, a glowing chemical from fireflies whose name makes some people think of the devil, the company suggested it would be policing such claims by making reference to the official vaccine ingredient list.
Whats actually on the official ingredient list? This week an elderly UK woman became the first person outside of a trial to get the newly approved vaccine developed by Pfizer and BioNTech, and the US could greenlight the same inoculation as soon as Thursday, December 10. Along with the regulatory actions over the last week have come the most detailed disclosures yet of the new vaccines makeup.
Here, for instance, is what the US Food and Drug Administration says is in Pfizers vaccine:
- Active Ingredient
- nucleoside-modified messenger RNA encoding the viral spike glycoprotein of SARS-CoV-2
So What Does The Content Of The Vaccine Look Like
What is mRNA? This is the active ingredient. The only active ingredient, actually. This is where a code for part of the genetic material for the virus is stored. The mRNA will assist in teaching your own body how to develop an immune response to the COVID19 virus. But rest assured, its not a live part of the virus. Its more like a set of instructions.
COVID-19 mRNA vaccines contain genetic material that gives instructions for your cells to make a piece of protein, the same ‘spike protein’ that is found on the surface of the virus that causes COVID-19. Your immune system recognises this protein does not belong there and begins to produce antibodies, training your body to respond if you get the real virus.
The cell breaks down and your body gets rid of the mRNA soon after it has used the instructions to train your immune system. It does not affect or interact with your DNA in any way. mRNA never enters the nucleus of the cell, which is where our DNA is kept.
mRNA vaccines are fairly new compared to other types of vaccines, but researchers have been studying and working with mRNA vaccines for decades.
mRNA vaccines have been studied and tested before for flu, Zika, rabies, and cytomegalovirus . mRNA has also been used in cancer research to trigger the immune system to target specific cancer cells.
What does a lipid look like on an ingredient list?
- dibasic sodium phosphate dihydrate
What does a sugar look like on an ingredient list?
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What About Allergies
For those worried about their allergies, the Pfizer and AstraZeneca vaccines do not contain human or animal products, or common allergens such as latex, milk, lactose, gluten, egg, maize/corn, or peanuts.
Allergic reactions to vaccines or their ingredients are very rare, but they do happen. In the US, a report from the Centres for Disease Control and Prevention suggested that severe allergic reaction was very rare at 11.1 instances per million doses of vaccine, and that more than 80 per cent of those cases occurred in people with a history of allergic reactions.
You must not get a COVID-19 vaccine if you have had any of the following:
- Anaphylaxis to a previous dose of the same COVID-19 vaccine
- Anaphylaxis after exposure to any ingredient of the COVID-19 vaccine.
If you have ever had a severe allergic reaction or anaphylaxis to anything else, including after receiving a vaccine, you can still get the vaccine, but you must tell the immunisation provider beforehand.
Vaccines are usually delivered in a healthcare setting by trained professionals who have the right medications and equipment on hand and know what to do if there is an issue.
If you are asked to wait around for 30 minutes after your vaccination, dont be alarmed. This is a standard procedure, depending on your medical history.
How Effective Is It
Early vaccine trial results published by Novavax revealed a strong antibody response to the vaccine in animals. By August 2020, early human trials showed strong antibody responses with no serious adverse events and few side effects.
Novavax announced on June 14, 2021, that the vaccine was 90.4% effective in a preliminary analysis of data from its Phase 3 trial in the U.S. and Mexico. It was also 100% effective against moderate and severe disease. The trial was conducted when the U.K. variant B.1.1.7, also known as the Alpha variant, was the predominant strain in the U.S.
This followed an announcement in late January that the vaccine was found to be 89.3% effective in its U.K. Phase 3 trial and included protection from the U.K. variant.
The company also announced that the vaccine was 60% effective in a Phase 2b clinical trial in South Africa and included protection from the South African variant B.1.351, also called the Beta variant.
In Novavax’s trial, participants were not directly exposed to the virus, but instead researchers used a natural infection approach. This method was also used for the three COVID-19 vaccines that received emergency use authorizations from the Food and Drug Administration .
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Who Should Have The Vaccines
The aim of the COVID-19 vaccination programme is to protect those who are most at risk of becoming seriously ill with COVID-19. Changes to recommendations in the UK vaccination programme from from the UK Joint Committee on Vaccination and Immunisation include:
- All adults in the UK are now eligible for first, second and booster doses. In England, Northern Ireland and Scotland, all adults over 18 can book their booster dose. In Wales, invitations to book booster doses will be sent out from the local health boards.
- The gap between the second dose and booster dose has been reduced to a minimum of three months .
- From 20th December 2021, all children aged 12-17 can book a second dose. Previously, two doses were only recommended for 16-17 year olds.
Severely Immunosuppressed Individuals:
- Fourth doses as a booster have been recommended for severely immunosuppressed individuals, a minimum of three months after their third dose.
Pregnancy and breastfeeding
The JCVI recommended that women who are breastfeeding may be offered two doses of COVID-19 vaccines. There is no known risk associated with receiving non-live vaccines whilst breastfeeding.
Following advice from the UK Joint Committee on Vaccination and Immunisation, the programme has vaccinated people in the order of highest risk of severe COVID-19 disease, due to occupation, age or other risk factors. The categories are outlined below:
Who cant have the vaccines?
Who Is The Vaccine Not Recommended For
Individuals with a history of anaphylaxis to any component of the vaccine should not take it.
Persons with acute PCR-confirmed COVID-19 should not be vaccinated until after they have recovered from acute illness and the criteria for ending isolation have been met.
Anyone with a body temperature over 38.5°C should postpone vaccination until they no longer have a fever.
Most children and adolescents are at very low risk of severe COVID-19. Safety and immunogenicity data are currently being generated for those aged under 18 years. Until this data are available, vaccination of persons under the age of 18 is not recommended.
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Vaccine Ingredients And How They Work
How the Pfizer and Moderna Vaccines Work
Both the Pfizer and Moderna vaccines are messenger RNA vaccines. mRNA is a molecule that contains the blueprint for making proteins. These are the first mRNA vaccines to be available, but the technology has been studied for over 30 years.
Here is how mRNA vaccines work:
mRNA is similar to an email that gets sent to your body with instructions on how to identify and destroy the virus. Your body uses those instructions and then deletes the email completely.
How the Johnson & Johnson Vaccine Works
The Johnson & Johnson vaccine is an adenovirus vector vaccine. Johnson & Johnson has been researching adenovirus vector vaccines for other infections for decades. The companys Ebola vaccine is also an adenovirus vector vaccine and is already in use.
Here is how the Johnson & Johnson vaccine works:
The Pfizer and Moderna vaccines contain the following types of ingredients:
What Should I Do If I Experience Symptoms After Receiving A Covid
Some people have side effects after being vaccinated , which are normal signs that your body is building protection. These side effects may affect your ability to do daily activities, but they should go away in a few days. If you develop respiratory symptoms like runny nose, cough, or loss of sense of smell or taste, you should consider getting tested for COVID-19 or talk to your healthcare provider. It is possible to get COVID-19 even after you get the vaccine. Stay home if you are sick and avoid close contact with others. You may wish to check with your employer about how this will impact your work.
If you have any significant pain or discomfort, talk to your healthcare provider, who may recommend over-the-counter medicine, such as ibuprofen or acetaminophen. To reduce pain and discomfort where you got the shot apply a clean, cool, wet washcloth over the area, and use or exercise your arm. To reduce discomfort from fever, drink plenty of fluids and dress lightly. In most cases, discomfort from fever or pain is normal, but contact your healthcare provider if:
- the redness or tenderness where you got the shot increases after 24 hours
- your side effects are worrying you or do not seem to be going away after a few days
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What Is In The Shot
Like all vaccine ingredients, those in the COVID-19 vaccine serve a specific purpose. For instance, some ingredients help the vaccine work. Others are needed to help produce the vaccine.
Here are some of the other ingredients in the COVID-19 vaccines now in use. Ask your doctor if you have any concerns about them.
- Polyethylene glycol 2000 dimyristoyl glycerol .
- Sodium chloride.
How Long Do I Have To Wait Between The First And Second Dose Of The Covid
Your second shot is recommended at 21 days for Pfizer and 28 days for Moderna. However, if you get the second shot at any time after the recommended date, you are still considered fully vaccinated. You should not get the second dose earlier than 21 days for Pfizer or 28 days for Moderna. The Janssen vaccine is only one dose.
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Will Getting The Vaccine Negatively Impact A Persons Immigration Status
No. The federal government has confirmed that it will not consider COVID-19 treatment as part of a determination of whether someone is a public charge or as it relates to the public benefit condition for certain individuals seeking an extension of stay or change of status, even if the vaccine is paid for by Medicaid or other federal funds.