What About Johnson & Johnson
A new study released Tuesday suggested that the Johnson & Johnson COVID-19 vaccine might not be very effective against the delta and lambda variants. The study was not peer-reviewed or published in a medical journal. But the experts involved in the study do not work for any of the vaccine developers.
Do The Vaccines Protect Against The Variants
The optimism that came with the approval of COVID-19 vaccines in late 2020 was tempered by the emergence of several coronavirus variants that had mutated to be more contagious, deadlier, and potentially able to evade the vaccines.
But the data so far suggest that currently available vaccines work well against the variants.
Chen says that those who are vaccinated and later infected with one of the concerning variants are still unlikely to be hospitalized. Though there is little real-world data on how the vaccines work against the B.1.351 variant a particularly concerning one first detected in South Africa one small clinical trial for the AstraZeneca vaccine was halted after it showed only 22% efficacy against the variant. Notably, none of the vaccinated people, who were generally low-risk for severe COVID-19 to begin with, were hospitalized or died.
The World Health Organization says that the vaccines are likely to provide at least some protection against each of the variants because they prompt a broad immune response beyond just targeting the spike protein that is the focus of the vaccines.
Pfizer and Moderna have begun testing third booster shots of the vaccines to see if the extra dose could provide further protection against the variants. They are also developing variant-specific vaccines targeting the B.1.351 variant.
Edwards would not be surprised if it turns out that people need to continue to get COVID-19 booster shots as additional variants emerge.
Which Booster Shot Should I Get If I Got Pfizer
Both mRNA vaccines, Pfizer and Moderna, have proven to be effective and continue to protect against severe disease caused by COVID-19. A study published by the CDC in September that compared vaccine effectiveness among adults in the real world found that two doses of Moderna’s vaccine were 93% effective at preventing hospitalization, two doses of Pfizer were 88% effective and one dose of Johnson & Johnson was 71% effective.
Pfizer’s booster is the same dose as its original vaccine , while Moderna’s booster is half the size of its original vaccine. Johnson & Johnson’s booster is also the same size as its original vaccine . In a study that examined people’s responses to all three vaccines as boosters, people who originally got Pfizer had the strongest antibody response to a Moderna booster. However, that study examined a full dose of Moderna , rather than the authorized half-dose of the company’s booster, which likely minimizes Moderna’s edge over Pfizer, The Atlantic reported.
For most adults who were vaccinated with Pfizer, sticking with another dose of Pfizer makes the most sense, Dr. Robert Wachter, chair of UC San Francisco’s Department of Medicine, told the Los Angeles Times.
The definition of “fully vaccinated” hasn’t changed. A person is considered fully vaccinated two weeks after their second dose of Pfizer or Moderna, or two weeks after a single dose of Johnson & Johnson.
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How Fast Will The Booster Work
The boosters work a bit faster than the original course of the vaccine because your body isn’t starting from scratch, says Dr. Simone Wildes, who’s an infectious disease doctor at South Shore Health in Massachusetts.
“You already have some antibodies,” she says. “So I would anticipate that within a week or so after the booster, you’re going to have pretty significant levels of antibodies, but you’re not going to get to the maximum levels until the 14-day mark.”
So if you go get vaccinated today, you will have some antibody protection by New Year’s.
Both Vaccines Highly Effective Recommended
The researchers noted that the matched population during the period of Delta dominance was, on average, younger. This group also had a higher percentage of Black participants, current smokers, and those who had received no flu vaccinations in the previous 5 years at a VA facility and it included a lower percentage of those with underlying chronic conditions.
“The 24-week risk of COVID-19 outcomes was low after vaccination with mRNA-1273 or BNT162b2 , although risks were lower with mRNA-1273 than with BNT162b2,” the study authors wrote. “This pattern was consistent across periods marked by alpha- and delta-variant predominance.”
The researchers noted that although early clinical trials and then real-world observational studies found that the Pfizer and Moderna vaccines were both highly effective against symptomatic COVID-19 , no direct comparisons had been attempted.
In the VA news release, first author Barbra Dickerman, PhD, MSc, of Harvard said that both vaccines are recommended because they both are highly effective. However, while the estimated differences in effectiveness were small on an absolute scale, they may be meaningful when considering the large population scale at which these vaccines are deployed,” she said. “This information may be helpful for larger decision-making bodies.”
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Vials: Of: Moderna: And: Pfizer: Vaccinejpg
In the first head-to-head comparison of the Pfizer/BioNTech and Moderna mRNA COVID-19 vaccines, Moderna edged out its competition with a 21% lower risk of infection and a 41% lower risk of hospitalization over 24 weeks, according to a study yesterday in the New England Journal of Medicine .
A team led by researchers from Harvard University and the US Department of Veterans Affairs analyzed the electronic medical records of veterans nationwide, almost all of whom received two doses of either the Pfizer or Moderna COVID-19 vaccine from Jan 4 to May 14, 2021. The study period was dominated by the SARS-CoV-2 Alpha variant.
“Both vaccines are incredibly effective, with only rare breakthrough cases,” said study coauthor Juan Casas, MD, PhD, an epidemiologist at Brigham and Women’s Hospital in Boston and a Harvard associate professor, in a VA news release. “But regardless of the predominant strainAlpha earlier and then Delta laterModerna was shown to be slightly more effective.”
Are The Covid Vaccines Effective Against Omicron
Pfizer and its partner BioNTech announced last week that two doses of their vaccine appear to be less protective against COVID-19, but a booster dose restores some of that power. Officials at BioNTech also said that the companies could have an omicron-specific vaccine ready by March, if research shows it’s needed. Moderna said it’s studying the effectiveness of its vaccine and could make an omicron-specific vaccine if necessary. Johnson & Johnson said it’s working with officials in South Africa to evaluate its vaccine’s effectiveness and also started work on a vaccine specific to omicron, if it’s needed.
In an interview with NBC Nov. 28, Fauci said that even in the face of a variant of concern, you do well against it if you have the increased protection of a booster. “It may not be as good in protecting against initial infection, but it has a very important impact on diminishing the likelihood that you’re gonna get a severe outcome from it,” he said, adding that boosting gives an “extraordinary increase in protection.”
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Which Booster Shot Is The Best Protection Against Omicron Variant Of Covid
Here is what you need to know about the efficacy of the booster shots available in the United States and how they stack up against each other in regard to protection against the omicron variant of COVID-19.AP Photo/Alberto Pezzali
You cannot go wrong by getting a booster shot if you have not already.
But some booster shots appear to work better than others.
It is important to remember the data is constantly evolving. What is known, however, is all the vaccines prevent serious illness, hospitalization and death in most breakthrough cases where a fully vaccinated person tests positive for COVID-19.
Latest CDC data by vaccine status:Unvaccinated: 451 cases per 100kVaccinated: 134 cases per 100kBoosted: 48 cases per 100kUnvaccinated: 6.1 deaths per 100kVaccinated: 0.5 deaths per 100kBoosted: 0.1 deaths per 100k
Here is what you need to know about the efficacy of the booster shots available in the United States and how they stack up against each other in regard to protection against the omicron variant of COVID-19.
Omicron Calls For Covid Boosters Health Officials Say: How To Pick One
The CDC recommends Pfizer’s and Moderna’s vaccine over Johnson & Johnson’s. Here’s what to know about mixing and matching COVID-19 vaccines.
People should get Moderna’s or Pfizer’s COVID-19 vaccines instead of Johnson & Johnson’s, the US Centers for Disease Control and Prevention says, citing a rare risk for serious blood clots. That means US adults should choose between Pfizer’s or Moderna’s vaccine as a booster, though Johnson & Johnson’s is still available if someone can’t receive Pfizer or Moderna or wants to get the one-dose vaccine.
The new guidance followed discussion by a CDC panel over J& J’s link to a rare but dangerous blood-clotting disorder, which has occurred in both men and women and in higher rates than previously understood. Although rare overall it has caused nine deaths. Women ages 30 to 49 are at highest risk, with one in 100,000 women experiencing the disorder. The rare response to the vaccine occurs in the days or few weeks following the shot, so people who received Johnson & Johnson’s vaccine months ago aren’t at increased risk.
The definition of fully vaccinated hasn’t changed for the time being, but receiving an extra dose seems to bring back some protection lost with the newer coronavirus variant. “If you look at the data, the more and more it becomes clear that if you want to be optimally protected, you really should get a booster,” Fauci said.
As the booster rollout intensifies, here’s what to consider when choosing your extra dose.
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Selling Stock Like Clockwork Modernas Top Doctor Gets $1 Million Richer Every Week
It was a real obstacle, and still may be, but Karikó was convinced it was one she could work around. Few shared her confidence.
Every night I was working: grant, grant, grant, Karikó remembered, referring to her efforts to obtain funding. And it came back always no, no, no.
She was back to the lower rungs of the scientific academy.
Usually, at that point, people just say goodbye and leave because its so horrible, Karikó said.
Theres no opportune time for demotion, but 1995 had already been uncommonly difficult. Karikó had recently endured a cancer scare, and her husband was stuck in Hungary sorting out a visa issue. Now the work to which shed devoted countless hours was slipping through her fingers.
I thought of going somewhere else, or doing something else, Karikó said. I also thought maybe Im not good enough, not smart enough. I tried to imagine: Everything is here, and I just have to do better experiments.
In time, those better experiments came together. After a decade of trial and error, Karikó and her longtime collaborator at Penn Drew Weissman, an immunologist with a medical degree and Ph.D. from Boston University discovered a remedy for mRNAs Achilles heel.
That was a key discovery, said Norbert Pardi, an assistant professor of medicine at Penn and frequent collaborator. Karikó and Weissman figured out that if you incorporate modified nucleosides into mRNA, you can kill two birds with one stone.
When Do You Need To Get A Covid
As mentioned above, booster shot timelines can slightly vary. Thankfully, theres a general framework to follow.
If you received a Pfizer or Moderna vaccine, you need to wait at least 6 months before you get your booster shot. The clock starts ticking after you get your second dose. So, if you received your second Pfizer or Moderna dose on June 1, 2021, you would be eligible for a booster shot on December 1, 2021.
But if you initially received the single-dose J& J vaccine, you only need to wait at least 2 months. If you received a J& J vaccine on October 1, 2021, you would be eligible for a booster shot on December 1, 2021.
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Getting Your Second Dose Of The Covid Vaccine Here’s What You Should Know
Unlike the Pfizer and Moderna shots, the J& J vaccine uses a cold virus, called an adenovirus, to carry the spike gene into the body. J& J uses a human adenovirus to create its vaccine while a similar vaccine not yet approved in the U.S., AstraZeneca, uses a chimpanzee version.
J& Js shot uses a cold virus like a Trojan horse to carry the spike gene into the body, where cells make harmless copies of the protein to prime the immune system in case the real virus comes along. Its the same technology the company used in making an Ebola vaccine.
Is A Booster Shot The Same As An Additional Dose
You may have seen the terms booster shot and additional dose used interchangeably. They seem like similar terms, so shouldnt they mean the same thing?
Unfortunately, thats not the case. A booster shot is different from an additional dose.
An additional dose is given to someone whose immune response to their initial shots isnt enough to provide adequate protection. This includes people with weakened immune systems. Thats why an additional dose is recommended for people with weakened immune systems at least 28 days after their second Pfizer or Moderna shot.
A booster shot is given because protection from a vaccine can lessen over time. In other words, the level of protection you had after becoming fully vaccinated may drop over the course of 6 months. Booster shots can help boost your protection back up to an adequate level.
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Moderna Says Booster Dose Of Its Covid
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Dec 20 – Moderna Inc said on Monday that a booster dose of its COVID-19 vaccine appeared to be protective against the fast-spreading Omicron variant of the coronavirus in laboratory testing and that the current version of the shot would continue to be its “first line of defense against Omicron.”
The company said its decision to focus on the current vaccine, mRNA-1273, was driven in part by how quickly the recently-discovered variant is spreading.
Moderna said it still plans to develop a vaccine to protect against Omicron specifically and hopes to start clinical trials early next year.
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“What we have available right now is 1273,” Dr. Paul Burton, Moderna’s chief medical officer, said in an interview. “It’s highly effective, and it’s extremely safe. I think it will protect people through the coming holiday period and through these winter months, when we’re going to see the most severe pressure of Omicron.”
Moderna’s shares were down more than 4% at $282.26 in afternoon trading.
The company said a two-dose course of its vaccine generated low neutralizing antibodies against the Omicron variant, but a 50-microgram booster dose increased neutralizing antibodies against the variant 37 fold. A 100-microgram booster – the same strength as the original shots – drove neutralizing antibodies to more than 80 times pre-boost levels.
Evidence And Expert Opinion Help One Staff Writer Vaccine Decide Which Dose To Get Next
Now that people can mix and match COVID-19 vaccines, choosing one for a booster dose may be complicated. Reviewing the data on and talking to scientists about the vaccines from Pfizer/BioNTech, Moderna, Johnson & Johnson and AstraZeneca can help inform that decision.
Its been a little over six months since I got my second dose of the COVID-19 vaccine from Pfizer and its German partner BioNTech, and a phone call from my state health department over the weekend reminded me that I am eligible for a booster. But do I really need to get a third COVID-19 shot? If so, which of the three authorized or approved vaccines available in the United States should I get? To make my decision, I looked at the evidence and talked to some experts. What I found out could be useful to anyone deciding on a booster.
Lets start with Johnson & Johnson. Everyone who got that shot as their initial vaccine is recommended to get a booster two months after the first jab, U.S. health officials and experts say . Thats because the antibody response from that one-dose vaccine isnt as high as for the two-dose mRNA vaccines from Pfizer and Moderna, and it is waning. It doesnt go away entirely, says Sachin Nagrani, medical director of Heal, a company that provides primary health care in peoples homes via telehealth visits and house calls. But a few months after the J& J shot, it seems like your immune response is less protective.
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Does That Mean J& j Recipients Should Get A Moderna Booster
There’s no way to be certain, according to Dr. Robert Wachter, chair of UC San Francisco’s Department of Medicine.
“Its logical to believe that higher antibodies are correlated with more protection, but its more complicated than that,” Wachter wrote in an email to The Times. There are several different components to the immune system, and the “level of antibodies doesnt always line up with true protection.”
That said, “I think it would be reasonable for a J& J person to get either a Pfizer or Moderna shot,” Wachter said. “If theyre equally easy to get, then I might slightly favor Moderna. Id prefer either over another J& J.
“Its pretty unlikely that there is really a material difference in 35 versus 76 times higher,” Wachter said of the differences in antibody levels between Pfizer and Moderna boosters for original Johnson & Johnson recipients. “Theyre both so high that they cross the threshold for a high level of protection.”
The director of the CDC, Dr. Rochelle Walensky, declined to give a solid recommendation on which boosters were best.
“If you’ve got J& J followed by a Moderna or Pfizer, you got a really robust antibody response. But we saw some data, also from J& J, that demonstrated that J& J folks who got boosted with J& J had a really good clinical response as well,” Walensky told ABC News'”Good Morning America.””So, really, this is about personal preference and talking to your physician about what’s best for you.”