Global Statistics

All countries
593,393,961
Confirmed
Updated on August 12, 2022 4:07 am
All countries
563,612,986
Recovered
Updated on August 12, 2022 4:07 am
All countries
6,448,976
Deaths
Updated on August 12, 2022 4:07 am

Global Statistics

All countries
593,393,961
Confirmed
Updated on August 12, 2022 4:07 am
All countries
563,612,986
Recovered
Updated on August 12, 2022 4:07 am
All countries
6,448,976
Deaths
Updated on August 12, 2022 4:07 am
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What Is Covid Vaccine Ingredients

Q: How Is Additional Safety Monitoring Being Conducted For The Pfizer

Ask an Expert: What are the ingredients in the COVID vaccines?

A: The company has submitted a pharmacovigilance plan to the FDA to monitor the safety of the Pfizer-BioNTech COVID-19 Vaccine as it is used under EUA. The pharmacovigilance plan includes a plan to complete longer-term safety follow-up for participants enrolled in ongoing clinical trials. The pharmacovigilance plan also includes other activities aimed at monitoring the safety of the Pfizer-BioNTech COVID-19 vaccine and ensuring that any safety concerns are identified and evaluated in a timely manner.

Monophosphoryl Lipid A Saponin And Related Adjuvant Systems

Bigaeva E, van Doorn E, Liu H, Hak E. Meta-analysis on randomized controlled trials of vaccines with QS-21 or ISCOMATRIX adjuvant: safety and tolerability. PLoSONE 2016 11:e0154757. Saponin is an immunostimulant that is extracted from the bark of a South American tree, Quillaja sapnonaria. Two saponin-based adjuvants are QS21 and ISCOMATRIX. The authors conducted a systematic literature review to assess the safety and tolerability of saponin-based adjuvants and found no increase in the incidence of reported systemic adverse events.

Leroux-Roels G, Leroux-Roels I, Clement F, Ofori-Anyinam O, Lievens M, et al. Evaluation of the immune response to RTS,S/AS01 and RT,S/AS02 adjuvanted vaccines. Hum Vacc Immunother 2014 10:2211-2219.The authors compared the safety and immunogenicity of malaria vaccines adjuvanted with squalene, monophosphoryl lipid A and saponin to a non-adjuvanted malaria vaccine in adults and found greater immune responses with adjuvanted vaccines. Adjuvanted vaccines had a higher rate of injection site reactions and certain generalized reactions compared with the non-adjuvanted vaccine but within acceptable limits. These side effects typically resolved within seven days. No serious adverse events were reported for any group.

CpG

Q: For The Emergency Use Authorization Of A Booster Dose What Data Did Fda Evaluate Pertaining To The Effectiveness Of The Vaccine Against The Delta Variant Of Sars

A: An analysis compared the rates of COVID-19 accrued during the current Delta surge among original clinical trial participants who completed the two-dose vaccination series early in the clinical trial, to those who completed the two-dose series later in the study because they were originally randomized to the placebo group and received the vaccine later. The analysis showed that during the study period of July and August 2021, the incidence of COVID-19 was higher among the participants who completed their vaccine series earlier, compared to participants who completed the vaccine series later. FDA determined that the rate of breakthrough COVID-19 reported during this time period translates to a modest decrease in the efficacy of the vaccine among those vaccinated earlier, equivalent to one to five percent.

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Ingredients That Are Not Used In Covid

The above table lists ALL ingredients in the Pfizer-BioNTech COVID-19 vaccine. There are NO ingredients in this vaccine beyond what is listed in the table. The Pfizer-BioNTech COVID-19 vaccine has:

  • No preservatives like thimerosal or mercury or any other preservatives.
  • No antibiotics like sulfonamide or any other antibiotics.
  • No medicines or therapeutics like ivermectin or any other medications.
  • No tissues like aborted fetal cells, gelatin, or any materials from any animal.
  • No food proteins like eggs or egg products, gluten, peanuts, tree nuts, nut products, or any nut byproducts .
  • No metals like iron, nickel, cobalt, titanium, rare earth alloys, or any manufactured products like microelectronics, electrodes, carbon nanotubes or other nanostructures, or nanowire semiconductors.
  • No latex. The vial stoppers used to hold the vaccine also do not contain latex.

How Do Mrna Covid

Vaccine Frequently Asked Questions (Infographics)

In both the Pfizer-BioNTech and Moderna vaccines, the onlyactive ingredient is mRNA, which stands for ribonucleic acid.

Although the Covid-19 vaccines are the first time mRNA technology has been in an approved vaccine, the technology is something that scientists have worked on for decades. The pandemic just gave the scientists the resources and energy to get that work over the finish line.

Think of the mRNA molecules in the vaccine as a mail carrier. They contain specific instructions for our immune system. The instructions tell the cells in our arm how to make a viral protein. The viral protein then triggers a natural immune response in our body, just like it would if we were infected with the virus. Because these instructions are so specific, our immune system mounts a more robust antibody response than it would if weâd actually contracted the virus.

This response means our body has fighters ready to attack the virus if weâre exposed. This is why â even if breakthrough infections occur â people who are vaccinated are much less likely to require hospitalization or die from the disease.

Once the mRNA has delivered its instructions to the cells, the body gets rid of it. The conspiracy theories that suggest mRNA can alter DNA are completely unfounded. mRNA vaccines never enter the nucleus of the cell, which is where our DNA is stored. The mail carrier is just putting the mail in the mailbox on the sidewalk outside your house, it never comes inside.

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Side Effects And Safety

The COVID-19 vaccines approved for use in the UK have met strict standards of safety, quality and effectiveness.

They can cause some side effects, but not everyone gets them.

Any side effects are usually mild and should not last longer than a week, such as:

  • a sore arm from the injection
  • feeling tired

Q: Must Vaccine Providers Give A Hard Copy Of The Authorized Vaccine Information Fact Sheet For Recipients And Caregivers To The Individual When They Get Each Dose Of Their Vaccine

A: The EUA requires vaccination providers, prior to the individual receiving the vaccine, to communicate to the recipient or their caregiver information consistent with the Vaccine Information Fact Sheet for Recipients and Caregivers, and either to provide a copy of the Vaccine Information Fact Sheet for Recipients and Caregivers or to direct the individual to the CDC’s website to obtain the fact sheet.

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Who Should Have The Vaccines

The aim of the COVID-19 vaccination programme is to protect those who are most at risk of becoming seriously ill with COVID-19. Changes to recommendations in the UK vaccination programme from from the UK Joint Committee on Vaccination and Immunisation include:

Adults:

  • All adults in the UK are now eligible for first, second and booster doses. In England, Northern Ireland and Scotland, all adults over 18 can book their booster dose. In Wales, invitations to book booster doses will be sent out from the local health boards.
  • The gap between the second dose and booster dose has been reduced to a minimum of three months .

Children:

  • From 20th December 2021, all children aged 12-17 can book a second dose. Previously, two doses were only recommended for 16-17 year olds.

Severely Immunosuppressed Individuals:

  • Fourth doses as a booster have been recommended for severely immunosuppressed individuals, a minimum of three months after their third dose.

Immunosuppression

Pregnancy and breastfeeding

The JCVI recommended that women who are breastfeeding may be offered two doses of COVID-19 vaccines. There is no known risk associated with receiving non-live vaccines whilst breastfeeding.

Children

Priority Groups

Following advice from the UK Joint Committee on Vaccination and Immunisation, the programme has vaccinated people in the order of highest risk of severe COVID-19 disease, due to occupation, age or other risk factors. The categories are outlined below:

Who cant have the vaccines?

Are Any Of The Vaccine Ingredients Toxic Or Dangerous

Are the Ingredients in the COVID-19 Vaccine safe?

At the small doses planned for these vaccines, none of the chemicals above are expected to be toxic or dangerous. mRNA by itself is not dangerous. In fact, there is mRNA inside the cells of all plants and animals.

The vaccines were able to be developed quickly because these companies were already studying mRNA to make vaccines and medications against other diseases. Because of this, there is a great deal of research about all of the ingredients in Pfizer and Modernas COVID-19 vaccines in peer-reviewed scientific literature.

Since the COVID-19 vaccines use a genetic sequence instead of killed or weakened viruses to create an immune response, there is no chance you will get COVID-19 from the vaccine. It also means these vaccines are much easier to manufacture than other types of vaccines.

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How Does A Vaccine Work

The COVID-19 vaccine, just like any other vaccine, works by teaching your immune system how to defend itself against attack from the virus. The vaccine contains a harmless bit of the virus, so that your body produces white blood cells. If you were then to become infected with COVID-19, your body would have the memory of the partial bit of the virus and would be able to fight it immediately. None of the vaccines contain a live form of the virus in them.

Q What Information Is Available About Myocarditis And Pericarditis Following Vaccination With Pfizer

A. Post-authorization safety surveillance data pertaining to myocarditis and pericarditis demonstrate increased risks of myocarditis and pericarditis, particularly within 7 days following the second dose of the Pfizer-BioNTech COVID-19 Vaccine, with the risk being higher in males under 40 years of age than in females or older males. The observed risk is highest in males 12 through 17 years of age.

The Fact Sheet for Healthcare Providers Administering Vaccine for the Pfizer-BioNTech COVID-19 Vaccine includes a warning about the risk of myocarditis and pericarditis, and the Vaccine Information Fact Sheet for Recipients and Caregivers include information about myocarditis and pericarditis. The Vaccine Information Fact Sheet for Recipients and Caregivers notes that vaccine recipients should seek medical attention right away if they experience any of the following symptoms after vaccination:

  • Chest pain

A: Yes. Providers administering Pfizer-BioNTech COVID-19 Vaccine must report to the Vaccine Adverse Event Reporting System and to Pfizer the following information associated with the vaccine of which they become aware:

  • Vaccine administration errors whether or not associated with an adverse event
  • Serious adverse events
  • Cases of Multisystem Inflammatory Syndrome
  • Cases of COVID-19 that result in hospitalization or death

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What Are The Ingredients Of Pfizers Covid

We asked experts to help us decode the contents.

Facebook said on December 3 that it would remove posts with false claims or conspiracy theories about whats in the covid-19 vaccines that everyones counting on.

In the face of rumors suggesting that Bill Gates has installed tracking microchips in the shots, or that the inoculations contain luciferase, a glowing chemical from fireflies whose name makes some people think of the devil, the company suggested it would be policing such claims by making reference to the official vaccine ingredient list.

Whats actually on the official ingredient list? This week an elderly UK woman became the first person outside of a trial to get the newly approved vaccine developed by Pfizer and BioNTech, and the US could greenlight the same inoculation as soon as Thursday, December 10. Along with the regulatory actions over the last week have come the most detailed disclosures yet of the new vaccines makeup.

Here, for instance, is what the US Food and Drug Administration says is in Pfizers vaccine:

  • Active Ingredient
  • nucleoside-modified messenger RNA encoding the viral spike glycoprotein of SARS-CoV-2
  • Lipids
  • ,2–N,N-ditetradecylacetamide
  • 1,2-distearoyl-snglycero-3-phosphocholine
  • Other
  • sucrose
  • What Share Of The Population Has Been Fully Vaccinated Against Covid

    What You Should Know About the COVID

    The following chart shows the share of the total population that has been fully vaccinated against COVID-19. This represents the share that have received all doses prescribed by the vaccination protocol. If a person receives the first dose of a 2-dose vaccine, this metric stays the same. If they receive the second dose, the metric goes up by 1.

    This data is only available for countries which report the breakdown of doses administered by first and second doses.

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    What Are The Ingredients In The Astrazeneca Vaccine

    This explainer is more than 90 days old. Some of the information might be out of date or no longer relevant. Browse our homepage for up to date content or request information about a specific topic from our team of scientists.

    This article has been translated from its original language. if you have any feedback on the translation.

    The AstraZeneca vaccine is made up of a number of ingredients, including an active ingredient called an ‘antigen’ and several other non-active ingredients called ‘excipients.’ These ingredients range from forms of salt that help preserve the vaccine to water that dilutes it into the right concentration.

    The AstraZeneca vaccine is made up of a number of ingredients, including an active ingredient called an ‘antigen’ and several other non-active ingredients called ‘excipients.’ These ingredients range from forms of salt that help preserve the vaccine to water that dilutes it into the right concentration.

    How Well The Vaccine Works

    • Based on evidence from clinical trials in people ages 16 years and older, the Pfizer-BioNTech vaccine was 95% effective at preventing laboratory-confirmed infection with the virus that causes COVID-19 in people who received two doses and had no evidence of being previously infected.
    • In clinical trials, the Pfizer-BioNTech vaccine had > 90% efficacy in preventing laboratory-confirmed COVID-19 infection in children ages 515 years, and the immune response in children ages 515 years was at least as strong as the immune response in people ages 1625 years.
    • In clinical trials, the vaccine also had > 90% efficacy in preventing COVID-19 among people of diverse age, sex, race, and ethnicity categories and among people with underlying medical conditions.
    • Evidence shows mRNA COVID-19 vaccines offer similar protection in real-world conditions as they have in clinical trial settingsreducing the risk of COVID-19, including severe illness, by 90% or more among people who are fully vaccinated.
    • CDC will continue to provide updates as we learn more.

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    For Children Under 5 Are The Vaccine Ingredients The Same

    Not exactly while the active ingredients of the Pfizer and BioNTech COVID-19 vaccines are identical to the current adult vaccines, the only difference is in the buffer called tromethamine used that allows for the childrens vaccine to remain refrigerated longer. While tromethamine may not sound like a common ingredient, from a scientific perspective, it was introduced into the worlds published literature in 1944 and is often used in cosmetics, serums, and vaccines since 1978.

    The other critical difference is in the dosage of 3 µg that will be administered in 3 doses for children under the age of 5 vs. the 10 µg dose that is given twice to children ages 5 and older and the 30 µg dose given 3 times to those ages 12 and above.

    Common Vaccine Side Effects May Include:

    VERIFY: What ingredients are in the COVID-19 vaccines?
    Symptoms at the injection site, such as:More general symptoms, such as:
    • redness

    A severe allergic reaction is rare. Signs and symptoms of anaphylaxis may include:

    • hives
    • swelling of the lips, face, tongue or airway
    • difficulty breathing
    • sudden low blood pressure
    • abdominal pain, vomiting and diarrhea

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    Pfizer Randomized Controlled Trial Offers Proof Beyond Doubt

    As most of my regular readers know, the topic of reinfections in vaccinated people was something I was interested in since the Fall of 2021. This issue is hugely important since if people can catch Covid more than once, this pandemic has the potential to never end.

    I wrote at least a dozen articles on this subject, such as this one:

    However, reinfections in vaccinated people were never proven in a large official randomized controlled trial, until now. As you know, randomized controlled trials offer the gold standard of evidence: randomize people between a vaccine group and a placebo group, and see if the vaccine group does better than the placebo group.

    Fortunately, we have data from Pfizers own official trial submitted to the FDA. This randomized controlled trial concerns vaccinating young kids and proved beyond doubt that vaccination causes repeated reinfections. Look at Page 38:

    What is that page saying? There were a total of 12 kids-participants who managed to get two COVID infections within the time frame of the trial. 11 of them were vaccine recipients and only one received no vaccine!

    Say that again?

    Out of 12 kids who had two COVID infections, only ONE was in the never-vaccinated group!

    Mind you, as the above passage says, all of these 12 reinfected children, never had Covid prior to the trial. So what caused vaccinated children to develop a disproportionate amount of repeat infections? The vaccine, of course. It is a randomized controlled trial, after all.

    The Development Of Adjuvants Is Tedious Work Bingbing Sun

    Flagellin isnt yet licensed for use in any human vaccine, but its shown promising results in trials.

    During a natural infection with bacteria, the protein binds to receptors on the surface of immune cells. This acts like a danger signal and encourages them to tell other immune cells to flock to the site leading to a protective response. In theory, this is also what happens when its included in vaccines. As with other adjuvants, it gets the attention of the immune system, so that the vaccine can do its job.

    So-called bacterial ghosts are another possibility, composed of the empty skins of bacteria. These are made by splitting open bacterial cells, such as those belonging to E. coli, so that you are left with the cell membrane and nothing else. Like squalene-based adjuvants, they lead to the production of chemical signals, which call for help from immune cells and maximise the chances of them finding the vaccine.

    The development of adjuvants is tedious work, says Sun. I mean, you have to make sure of the safety as well as the efficacy and this takes time. For a traditional vaccine, it usually takes about 10-12 years for us to licence the vaccine.

    Who knows, nearly a century after Gaston Ramon experimented with breadcrumbs, the world of adjuvants might be about to get a modern makeover and the next generation looks set to be just as bizarre as they were to begin with.

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